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The world’s first portablein-vivo­ tear osmolarity testing device

  • Quantitative measurement
  • Rapid results
  • Handheld, light & simple to use
  • Affordable point-of-care testing

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The I-PEN® Tear Osmolarity System


I-PEN®, the world’s first portable device to detect and measure the tear film osmolarity levels associated with dry eye disease.

  • Quantitative measurement of osmolarity
  • Affordable point-of-care test
  • Quick and simple to use (Entire test can be done in seconds)
  • Reproducible, accurate, and reliable results
  • Uses Single-Use-Sensors (SUS)


The I-PEN® Tear Osmolarity System is a sophisticated electronic system designed for the quantitative measurement of osmolarity (concentration of dissolved salts in solution) of human tears in normal and dry eye disease patients.

The I-PEN®, used in conjunction with the I-PEN® Single Use Sensors (SUS), provides a quick and simple method for determining tear osmolarity of the tissues bathed in the tear film of the orbital tissues such as the palpebral conjunctiva. After approximately 2 seconds of contact with the eyelid tissue, the I-PEN® Tear Osmolarity system will display a quantitative tear osmolarity test result on the liquid crystal display (LCD) in units of mOsms/L. No calculations required. The I-PEN® Tear Osmolarity System utilizes an impedance measurement to provide an indirect assessment of osmolarity of the tear film of the eye.

The I-PEN® Tear Osmolarity System is designed for use as an in-practice measurement tool both for patients presenting with dry eye symptoms and for all pre-and post-surgical patients. In addition, the I-PEN® Tear Osmolarity System is an invaluable asset for monitoring the progress of dry eye treatment therapies. The I-PEN® Tear Osmolarity System is for professional in-vivo use only.

Its ease of use, portability, and rapid result output make it a user-friendly tool for eye care professionals.

Key features:

  1. Innovative Technology: The I-PEN® Tear Osmolarity System utilizes an impedance measurement for an indirect appraisal of the tear film on the eye, leading the way in tear analysis technology.
  2. Speed and Precision: With the I-PEN® Tear Osmolarity System, tear analysis has never been quicker or more accurate. Get results in as little as 2 seconds without the need for additional calculations.
  3. User-Friendly Design: The I-PEN® Tear Osmolarity System combines the power of advanced technology with the convenience of a user-friendly interface, making it an essential tool for professionals.
  4. Portable and Convenient: With its compact design, the I-PEN® Tear Osmolarity System can easily be used in different settings, offering portability without compromising on precision.
  5. Advanced Care: The I-PEN® Tear Osmolarity System is also suitable for pre-and post-surgical patients, enhancing patient care and treatment monitoring.
  6. Enhanced Patient Experience: With its quick results and simple operation, the I-PEN® Tear Osmolarity System offers an improved patient experience, reducing the time spent on testing, while increasing comfort.
  7. Professional Use: The I-PEN® Tear Osmolarity System is intended for professional, in-clinic use only, offering a sophisticated and reliable tool for monitoring the progress of dry eye treatment therapies.

The Dry Eye Workshop II (DEWS II) is a comprehensive diagnostic protocol for Dry Eye Disease that emphasizes tear film instability and hyperosmolarity as key factors.

The I-PEN® Tear Osmolarity System aligns well with the DEWS II protocol in several ways:

  1. Tear Osmolarity Measurement: The DEWS II report identifies tear osmolarity as a critical determinant of Dry Eye Disease. The I-PEN® Tear Osmolarity System can quantitatively measure tear film osmolarity levels, helping to identify patients with dry eye.
  2. Speed and Efficiency: DEWS II protocol emphasizes the need for swift and accurate detection of dry eye conditions. With the ability to display results in as little as 2 seconds, the I-PEN® Tear Osmolarity System increases the efficiency of diagnostic procedures.
  3. Comprehensive Patient Care: The I-PEN® Tear Osmolarity System is suitable for both pre-and post-surgical patients, aligning with DEWS II’s holistic approach to patient care, which includes monitoring and managing the disease’s progression.
  4. Monitoring Disease Progression: The DEWS II protocol underscores the significance of monitoring treatment effectiveness over time. The I-PEN® Tear Osmolarity System is an invaluable tool in this regard, providing accurate measurements that can help eye care professionals track the progress of dry eye treatment therapies.
  5. In-Practice Screening: The DEWS II protocol recognizes the importance of in-practice screening for early detection and management of Dry Eye Disease. The I-PEN® Tear Osmolarity System is a professional tool designed to measure tear film osmolarity, helping eye care professionals in the dry eye diagnostic process.
  6. User-Friendly Design: DEWS II protocol aims for patient comfort during the diagnostic process. The I-PEN® Tear Osmolarity System, with its user-friendly interface, ensures a comfortable and efficient patient experience.

By aligning with the DEWS II protocol, the I-PEN® Tear Osmolarity System contributes to a more effective and comprehensive diagnostic process for Dry Eye Disease.

The I-PEN® Tear Osmolarity System requires:

  • Single-Use-Sensors (SUS) sold separately
  • Replacement battery CR2032 (available at most retailers)

To Be Used In Conjunction With I-PEN® Single Use Sensors (SUS)

  • Designed for in-vivo use with I-PEN®
  • Accurate and reliable results
  • Individually wrapped for single use
  • Affordable
  • Box contains 50 sensors

For more information about the I-PEN® Tear Osmolarity System or to arrange for an in-office demonstration, please contact your local I-MED Pharma sales rep or customer service @ 514-685-8118 or 1-800-463-1008.


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